inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56, RHEA:11392]
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity is a hydrolytic enzyme that catalyzes the removal of a phosphate group from the 5-position of inositol-1,3,4,5-tetrakisphosphate (IP4), producing inositol-1,3,4-trisphosphate (IP3). IP4 is a second messenger molecule involved in a variety of cellular processes, including signal transduction, membrane trafficking, and cell growth. The removal of the phosphate group from the 5-position of IP4 by inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity plays a critical role in regulating the levels of IP4 and IP3, which in turn regulate these cellular processes. Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity is a key enzyme in the inositol phosphate signaling pathway, and its activity is tightly regulated by a variety of factors, including protein-protein interactions, phosphorylation, and calcium levels. The activity of inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity is essential for maintaining proper cellular function, and mutations in the genes encoding this enzyme can lead to a variety of diseases, including cancer and neurological disorders.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Inositol polyphosphate-5-phosphatase A | An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14642] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| inositol 1,4,5-trisphosphate | Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. | myo-inositol trisphosphate | mouse metabolite |