Target type: molecularfunction
Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. [RHEA:21508]
Retinyl-palmitate esterase activity is an enzymatic process involved in the hydrolysis of retinyl palmitate, a major storage form of retinol (vitamin A) in the body. Retinyl palmitate esterase is a hydrolase that specifically cleaves the ester bond between retinol and palmitic acid, releasing retinol and palmitic acid as products. This reaction is essential for the mobilization of retinol from its storage form, making it available for various biological functions. Retinyl palmitate esterase is typically found in the small intestine, liver, and other tissues involved in vitamin A metabolism. It plays a crucial role in the absorption and transport of retinol from the diet, as well as in the regulation of retinol levels in the body. The activity of retinyl-palmitate esterase is regulated by factors such as dietary intake of vitamin A, hormonal signals, and other metabolic cues. Deficiency of retinyl-palmitate esterase can lead to impaired vitamin A absorption and utilization, resulting in vitamin A deficiency and related health problems.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Patatin-like phospholipase domain-containing protein 2 | A patatin-like phospholipase domain-containing protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96AD5] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| atglistatin | atglistatin : A biphenyl that is 1,1'-biphenyl substituted by (dimethylcarbamoyl)amino and dimethylamino groups at positions 3 and 4', respectively. It is a potent inhibitor of adipose triglyceride lipase activity (IC50 = 700nM). atglistatin: inhibits adipose triglyceride lipase; structure in first source |