glucose 1-dehydrogenase [NAD(P)] activity

Definition

Target type: molecularfunction

Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. [EC:1.1.1.47]

Glucose 1-dehydrogenase [NAD(P)] activity catalyzes the oxidation of glucose to gluconolactone, utilizing either NAD+ or NADP+ as a cofactor. This enzymatic reaction is a crucial step in various metabolic pathways, particularly in the utilization of glucose as an energy source. The enzyme facilitates the transfer of electrons from glucose to the nicotinamide cofactor, resulting in the reduction of NAD+ or NADP+ to NADH or NADPH, respectively. The generated NADH or NADPH can then participate in other metabolic reactions, such as electron transport chains, ultimately contributing to ATP production. Furthermore, glucose 1-dehydrogenase [NAD(P)] activity plays a significant role in the detoxification of glucose analogs and the biosynthesis of certain carbohydrates. This enzyme can also be involved in the production of gluconolactone, which is a precursor to gluconic acid, an important component in various industrial applications. The activity of this enzyme is often regulated by factors such as substrate concentration, cofactor availability, and pH.'
"

Proteins (1)

Compounds (1)