glucose 1-dehydrogenase (NADP+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]

Glucose 1-dehydrogenase (NADP+) catalyzes the oxidation of glucose to gluconolactone, with NADP+ as the electron acceptor. This enzyme plays a key role in the pentose phosphate pathway, an alternative pathway for glucose metabolism that is responsible for the production of NADPH and the precursor for nucleotide biosynthesis. NADPH is essential for reducing power in various metabolic processes, including the synthesis of fatty acids and steroids, and protection against oxidative stress. Glucose 1-dehydrogenase (NADP+) is a key enzyme in the detoxification of reactive oxygen species. In the presence of high levels of glucose, it can oxidize glucose to gluconolactone, which can then be further metabolized to gluconate, a process that generates NADPH. NADPH is used by glutathione reductase to reduce oxidized glutathione, which is then used to detoxify reactive oxygen species. In addition to its role in the pentose phosphate pathway and detoxification, glucose 1-dehydrogenase (NADP+) may also be involved in other biological processes, such as the regulation of cell growth and differentiation.'
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Proteins (1)

Compounds (1)