Target type: molecularfunction
Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+. [EC:4.6.1.6, RHEA:14737]
Cytidylate cyclase activity refers to the enzymatic conversion of cytidine 5'-monophosphate (CMP) into cyclic cytidine monophosphate (cCMP). This reaction involves the formation of a cyclic phosphodiester bond between the phosphate group at the 5' position of CMP and the hydroxyl group at the 3' position of the ribose sugar. This process is catalyzed by cytidylate cyclases, a family of enzymes that are typically transmembrane proteins.
Cytidylate cyclase activity plays a crucial role in various cellular processes, including:
* **Signal transduction:** cCMP acts as a second messenger in signaling pathways. It activates downstream signaling molecules like protein kinases, phosphatases, and ion channels, ultimately leading to changes in cellular functions.
* **Regulation of gene expression:** cCMP can modulate the expression of specific genes by influencing the activity of transcription factors.
* **Neurotransmission:** cCMP is implicated in neuronal signaling, particularly in the regulation of synaptic plasticity and memory formation.
* **Immune response:** cCMP contributes to the immune response by regulating the activity of immune cells.
The specific functions of cytidylate cyclase activity can vary depending on the cell type and the specific cytidylate cyclase enzyme involved. However, its role as a key regulator of intracellular signaling and cellular processes is well-established.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Guanylate cyclase soluble subunit beta-1 | A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02153] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gemfibrozil | aromatic ether | antilipemic drug | |
| 6-anilino-5,8-quinolinedione | 6-anilino-5,8-quinolinedione : A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. 6-anilino-5,8-quinolinedione: structure given in first source; SRS-A & guanylate cyclase antagonist | aminoquinoline; aromatic amine; p-quinones; quinolone | antineoplastic agent; EC 4.6.1.2 (guanylate cyclase) inhibitor |
| 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole | 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation. | aromatic primary alcohol; furans; indazoles | antineoplastic agent; apoptosis inducer; platelet aggregation inhibitor; soluble guanylate cyclase activator; vasodilator agent |
| benzydamine | benzydamine : A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. Benzydamine: A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat. | aromatic ether; indazoles; tertiary amino compound | analgesic; central nervous system stimulant; hallucinogen; local anaesthetic; non-steroidal anti-inflammatory drug |
| bay 41-8543 | BAY 41-8543: structure in first source | pyrazolopyridine |