Target type: molecularfunction
Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+. [EC:3.1.1.71, RHEA:11552]
Acetylalkylglycerol acetylhydrolase activity is a molecular function that involves the hydrolysis of acetyl groups from acetylalkylglycerols. These enzymes are typically involved in the breakdown of lipids, particularly in the metabolism of plasmalogens, which are a type of phospholipid found in cell membranes. The specific substrate for this enzyme is an acetylalkylglycerol molecule, which contains an acetyl group attached to a glycerol backbone. The enzyme uses water to break the bond between the acetyl group and the glycerol, releasing acetate and an alkylglycerol molecule. The released acetate can be further metabolized in the cell, while the alkylglycerol can be used to synthesize other lipids or serve as a signaling molecule. This activity is crucial for maintaining lipid homeostasis and regulating various cellular processes, including membrane fluidity, signal transduction, and energy production.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Neutral cholesterol ester hydrolase 1 | A neutral cholesterol ester hydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PIU2] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | 1,6-bis(cyclohexyloximinocarbonyl)hexane: selective inhibitor of canine platelet diglyceride lipase | carbamate ester; organonitrogen compound | |
| orlistat | orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. | beta-lactone; carboxylic ester; formamides; L-leucine derivative | anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor |
| ol-135 |