glutamine-phenylpyruvate transaminase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine. [EC:2.6.1.64, RHEA:17593]
Glutamine-phenylpyruvate transaminase (GPT) activity is a crucial metabolic process that facilitates the transfer of an amino group from L-glutamine to phenylpyruvate, resulting in the production of L-phenylalanine and α-ketoglutarate. This reaction is catalyzed by the enzyme GPT, which belongs to the class of aminotransferases. GPT plays a vital role in the biosynthesis of phenylalanine, an essential amino acid required for protein synthesis and various metabolic pathways. The reaction involves the formation of a Schiff base intermediate between the enzyme and the amino group donor, L-glutamine, followed by the transfer of the amino group to the keto group of phenylpyruvate, resulting in the formation of L-phenylalanine and α-ketoglutarate. GPT activity is tightly regulated by factors such as substrate availability, enzyme concentration, and cofactor levels, ensuring proper phenylalanine synthesis and maintaining metabolic balance. This enzymatic activity is essential for normal physiological functions and disruptions in GPT activity can lead to various metabolic disorders.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Kynurenine--oxoglutarate transaminase 1 | A kynurenine--oxoglutarate transaminase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16773] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| indolepropionic acid | 3-(1H-indol-3-yl)propanoic acid : An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3. indolepropionic acid: structure in third source | indol-3-yl carboxylic acid | auxin; human metabolite; plant metabolite |
| indole-3-lactic acid | 3-(indol-3-yl)lactic acid : A hydroxy monocarboxylic acid that is lactic acid substituted by a 1H-indol-3-yl group at position 3. It is a metabolite of tryptophan. indole-3-lactic acid: RN given refers to cpd without isomeric designation | hydroxy monocarboxylic acid; indol-3-yl carboxylic acid | human metabolite |
| pf-04859989 | PF-04859989: a potent, brain-penetrant inhibitor of kynurenine aminotransferase II/KAT II with in vivo activity; structure in first source |