malate dehydrogenase (NADP+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. [EC:1.1.1.82]

Malate dehydrogenase (NADP+) is an enzyme that catalyzes the reversible interconversion of malate and oxaloacetate, using NADP+ as a cofactor. This reaction is crucial in various metabolic pathways, including the malate-aspartate shuttle, the glyoxylate cycle, and the C4 carbon fixation pathway. The enzyme plays a critical role in the transfer of reducing equivalents (electrons) from the cytosol to the mitochondria, facilitating the production of ATP through oxidative phosphorylation. In the malate-aspartate shuttle, malate dehydrogenase (NADP+) converts cytosolic malate to oxaloacetate, which is then transaminated to aspartate and transported into the mitochondria. Within the mitochondria, the reverse reaction occurs, regenerating malate and allowing for the transfer of reducing equivalents. In the glyoxylate cycle, malate dehydrogenase (NADP+) catalyzes the oxidation of malate to oxaloacetate, which is then converted to phosphoenolpyruvate, a precursor for gluconeogenesis. In the C4 carbon fixation pathway, the enzyme facilitates the regeneration of oxaloacetate from malate, ensuring the continued operation of this pathway for efficient carbon dioxide assimilation. The overall function of malate dehydrogenase (NADP+) is to contribute to the balance of redox state within the cell, facilitating the transfer of electrons between different cellular compartments and supporting various metabolic processes.'
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Proteins (1)

Compounds (1)