Page last updated: 2024-10-24

phosphatidylinositol-4-phosphate phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate. [PMID:10224048, RHEA:55652]

Phosphatidylinositol-4-phosphate phosphatase activity is a crucial enzymatic process involved in regulating cellular signaling pathways and maintaining cellular homeostasis. This activity refers to the ability of specific enzymes, known as phosphatidylinositol-4-phosphate phosphatases (PIP4Ks), to hydrolyze the phosphate group at the 4-position of phosphatidylinositol-4-phosphate (PIP2). This hydrolysis reaction converts PIP2 into phosphatidylinositol (PI), a key precursor for various signaling molecules. PIP4Ks play a pivotal role in controlling the levels of PIP2, a lipid that serves as a second messenger involved in a wide range of cellular processes, including membrane trafficking, cytoskeletal organization, and signal transduction. By modulating PIP2 levels, PIP4Ks can influence the activity of downstream signaling pathways and cellular functions.'
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Proteins (1)

ProteinDefinitionTaxonomy
Synaptojanin-1A synaptojanin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43426]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
epicatechin gallate(-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.

epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea
catechin;
gallate ester;
polyphenol
EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
ampelopsin(+)-dihydromyricetin : An optically active form of dihydromyricetin having (2R,3R)-configuration.

ampelopsin: hepatoprotective agent; isolated from Hovenia dulcis; RN given for (2R-trans)-isomer; structure in first source
dihydromyricetin;
secondary alpha-hydroxy ketone
antineoplastic agent;
antioxidant;
metabolite
epiafzelechin(-)-epiafzelechin : A catechin derivative having (2R,3R)-configuration.

epiafzelechin: antioxidant; 3'-deoxy form of epicatechin; structure in first source
catechinplant metabolite
pyrviniumpyrvinium : A quinolinium ion that is 1-methylquinolinium substituted by dimethylamino group at position 6 and a (E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl at position 2. It is a anthelminthic drug active against pinworms. The salts of pyrvinium can also be used as anticancer agents.

pyrvinium: RN given refers to parent cpd; synonyms vanquin & vankin refer to pamoate[2:1]; structure in Merck Index, 9th ed, #7810
quinolinium ionanthelminthic drug;
antineoplastic agent
trans-2,3',4,5'-tetrahydroxystilbenetrans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrolstilbenoid
chlorhexidinechlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
biguanides;
monochlorobenzenes
antibacterial agent;
antiinfective agent
eriodictyol 7-O-beta-D-glucopyranosidebeta-D-glucoside;
flavanone glycoside;
monosaccharide derivative;
trihydroxyflavanone
plant metabolite;
radical scavenger