neuromedin U binding

Definition

Target type: molecularfunction

Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. [GOC:jl, PMID:12584108]

Neuromedin U (NMU) binding is a complex process involving the interaction of the neuropeptide NMU with its cognate G protein-coupled receptors, namely NMU receptor 1 (NMUR1) and NMU receptor 2 (NMUR2). These receptors are expressed in various tissues and organs, including the brain, gastrointestinal tract, and cardiovascular system. Upon binding of NMU, the receptors undergo conformational changes, leading to the activation of intracellular signaling pathways. This activation involves the coupling of the receptor to heterotrimeric G proteins, specifically Gαq/11 and Gαi/o, which in turn activate downstream effector molecules. For NMUR1, the primary signaling pathway involves the activation of phospholipase C (PLC), leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of calcium from intracellular stores, while DAG activates protein kinase C (PKC). These signaling events contribute to a wide range of physiological responses mediated by NMU, including modulation of food intake, regulation of gastrointestinal motility, control of blood pressure, and influence on neuronal activity. The precise molecular mechanisms underlying NMU binding and its subsequent signaling cascade are still under investigation, but ongoing research is providing valuable insights into the role of this neuropeptide in various physiological processes.'
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Proteins (2)

Compounds (3)