D-glucuronate transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other. [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]

D-glucuronate transmembrane transporter activity involves the movement of D-glucuronate across a cell membrane. This process is crucial for various biological functions, including:

* **Detoxification:** Glucuronidation, the conjugation of D-glucuronate to various molecules such as steroids, bilirubin, and drugs, enhances their water solubility and facilitates their excretion. By transporting D-glucuronate, the transporter ensures efficient detoxification processes.

* **Carbohydrate metabolism:** D-glucuronate is a precursor for the biosynthesis of glycosaminoglycans, components of the extracellular matrix. The transporter's role in supplying D-glucuronate is vital for maintaining proper extracellular matrix structure and function.

* **Cellular signaling:** Some studies suggest that D-glucuronate might play a role in cellular signaling pathways, though the exact mechanisms remain under investigation. The transporter's function in maintaining D-glucuronate levels could potentially influence these signaling pathways.

* **Maintaining cellular homeostasis:** The transporter contributes to cellular homeostasis by regulating the intracellular and extracellular concentration of D-glucuronate. This balance is essential for various metabolic processes and cellular integrity.

The molecular mechanism of D-glucuronate transmembrane transport involves the transporter protein binding to D-glucuronate on one side of the membrane. This binding triggers conformational changes in the transporter, allowing the D-glucuronate to move across the membrane to the other side. The transporter's specificity for D-glucuronate ensures the efficient and selective transport of this molecule. The activity of D-glucuronate transmembrane transporters is tightly regulated, ensuring that the appropriate levels of D-glucuronate are maintained within the cell and its surroundings.'
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Proteins (1)

Compounds (2)