histone H3K14 acetyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). [GOC:vw, PMID:21289066]

Histone H3 lysine 14 acetyltransferase activity is a crucial enzymatic function that plays a vital role in the regulation of chromatin structure and gene expression. This activity is catalyzed by histone acetyltransferases (HATs), a family of enzymes that transfer an acetyl group from acetyl coenzyme A (acetyl-CoA) to the ε-amino group of lysine 14 on histone H3. This post-translational modification, known as acetylation, alters the electrostatic charge of histone H3, leading to a more relaxed chromatin structure. The loosened chromatin structure allows for increased access of transcription factors and other regulatory proteins to DNA, facilitating gene transcription. Additionally, acetylation at H3K14 can also influence the recruitment of other histone modifying enzymes, further shaping the chromatin landscape. The intricate interplay between histone H3K14 acetylation and other epigenetic modifications contributes to the precise control of gene expression, playing a critical role in various cellular processes, including development, cell cycle regulation, and DNA repair.'
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Proteins (2)

Compounds (2)