bis(5'-adenosyl)-pentaphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. [PMID:10085096, PMID:9450008]

Bis(5'-adenosyl)-pentaphosphatase (also known as Ap5A hydrolase) is a hydrolase enzyme responsible for the hydrolysis of bis(5'-adenosyl) pentaphosphate (Ap5A) into two molecules of adenosine 5'-monophosphate (AMP). Ap5A is a dinucleotide that serves as a signaling molecule in various cellular processes.

Ap5A hydrolase plays a crucial role in regulating cellular signaling pathways by controlling the levels of Ap5A. The enzyme specifically cleaves the diphosphate bridge between the two adenosine moieties in Ap5A. This hydrolysis reaction releases two AMP molecules, which can then participate in other metabolic processes or be further degraded.

The molecular function of Ap5A hydrolase is crucial for maintaining cellular homeostasis. By regulating Ap5A levels, it influences diverse cellular functions, including:

* **Signal transduction:** Ap5A is involved in various signaling pathways, including the regulation of cell growth, differentiation, and apoptosis.
* **DNA replication and repair:** Ap5A can inhibit DNA polymerases, and Ap5A hydrolase activity is essential for maintaining DNA integrity.
* **Metabolic regulation:** Ap5A hydrolase can influence the activity of other enzymes involved in metabolism.

In summary, Ap5A hydrolase is a critical enzyme responsible for the hydrolysis of Ap5A, a signaling molecule involved in various cellular processes. Its activity is essential for maintaining cellular homeostasis and regulating cellular signaling pathways.'
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Proteins (2)

Compounds (3)