Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

An ectonucleotide pyrophosphatase/phosphodiesterase family member 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14638]

Synonyms

E-NPP 3;
NPP3;
Phosphodiesterase I beta;
PD-Ibeta;
Phosphodiesterase I/nucleotide pyrophosphatase 3

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
Reactive blue 2	Homo sapiens (human)	Ki	0.7100	2	2
adenosine 5'-diphosphate 2',3'-dialdehyde	Homo sapiens (human)	Ki	0.9500	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
nucleic acid binding	molecular function	Binding to a nucleic acid. [GOC:jl]
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	molecular function	Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. [EC:3.6.1.17, PMID:4955726]
phosphodiesterase I activity	molecular function	Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
bis(5'-adenosyl)-pentaphosphatase activity	molecular function	Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. [PMID:10085096, PMID:9450008]
nucleoside triphosphate diphosphatase activity	molecular function	Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. [EC:3.6.1.9]
bis(5'-adenosyl)-triphosphatase activity	molecular function	Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+. [EC:3.6.1.29, RHEA:13893]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
apical plasma membrane	cellular component	The region of the plasma membrane located at the apical end of the cell. [GOC:curators]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
basophil activation involved in immune response	biological process	A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. [GOC:add, ISBN:0781735149]
pyrimidine nucleotide metabolic process	biological process	The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]
phosphate-containing compound metabolic process	biological process	The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai]
nucleoside triphosphate catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
negative regulation of mast cell activation involved in immune response	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response. [GOC:mah]
ATP metabolic process	biological process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. [GOC:go_curators]
negative regulation of inflammatory response	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
phosphate ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah]
negative regulation of mast cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of mast cell proliferation. [GOC:add, GOC:mah]