apolipoprotein receptor binding

Definition

Target type: molecularfunction

Binding to an apolipoprotein receptor. [GOC:BHF, GOC:rl]

Apolipoprotein receptor binding is a molecular function that describes the interaction between apolipoproteins and their cognate receptors on cell surfaces. Apolipoproteins are protein components of lipoproteins, which are complexes of lipids and proteins that transport lipids in the bloodstream. Apolipoproteins play crucial roles in lipid metabolism by facilitating the uptake, transport, and delivery of lipids to various tissues.

Apolipoprotein receptors are transmembrane proteins that recognize and bind specific apolipoproteins. This interaction initiates a cascade of events, including the endocytosis of the lipoprotein complex into the cell. Once inside the cell, the lipids are released from the lipoprotein and utilized for various metabolic processes.

The binding of apolipoproteins to their receptors is highly specific, mediated by the interaction of specific amino acid residues on the apolipoprotein with complementary regions on the receptor protein. This specificity ensures that each lipoprotein is directed to the appropriate target cell.

The molecular function of apolipoprotein receptor binding is essential for maintaining lipid homeostasis, preventing lipid accumulation in the blood, and providing cells with essential lipids for growth, development, and energy production. Disruptions in this process can lead to various metabolic disorders, such as hyperlipidemia, atherosclerosis, and heart disease.

Examples of apolipoprotein receptors include the LDL receptor (LDLR), which binds low-density lipoprotein (LDL), and the HDL receptor (SR-BI), which binds high-density lipoprotein (HDL). These receptors play critical roles in cholesterol metabolism and are tightly regulated by cellular signaling pathways.'
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Proteins (1)

Compounds (2)