cholesterol 24-hydroxylase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+. [EC:1.14.14.25, RHEA:22716]

Cholesterol 24-hydroxylase activity is a crucial enzymatic function involved in the metabolism and detoxification of cholesterol. It catalyzes the hydroxylation of cholesterol at the C24 position, converting it into 24S-hydroxycholesterol. This reaction is a critical step in the bile acid synthesis pathway, which plays a vital role in the elimination of excess cholesterol from the body. 24S-hydroxycholesterol serves as a precursor to bile acids, which are synthesized in the liver and secreted into the bile. Bile acids aid in the digestion and absorption of fats in the small intestine. In addition to its role in bile acid synthesis, cholesterol 24-hydroxylase activity is also involved in cholesterol homeostasis. It helps regulate the levels of cholesterol in the body by removing excess cholesterol from circulation. Furthermore, cholesterol 24-hydroxylase activity has been implicated in the regulation of immune responses and the development of certain types of cancers. The enzyme is expressed in various tissues, including the liver, brain, and immune cells. Its activity is tightly regulated by a complex interplay of factors, including hormones, dietary cholesterol levels, and other signaling molecules.'
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Proteins (2)

Compounds (6)