copper-dependent protein binding

Definition

Target type: molecularfunction

Binding to a protein or protein complex, in the presence of copper. [GOC:ecd, PMID:16884690]

Copper-dependent protein binding is a molecular function that involves the interaction of a protein with copper ions. Copper is an essential trace metal that plays a critical role in a variety of biological processes, including cellular respiration, antioxidant defense, and neurotransmission. Copper-dependent proteins typically contain one or more copper binding sites, which are often located in specific structural domains. These binding sites can vary in their coordination chemistry and can be composed of amino acid residues such as histidine, cysteine, and methionine. The binding of copper to these sites can induce conformational changes in the protein, which can alter its activity or stability. In some cases, copper binding can also facilitate the formation of protein complexes. The precise molecular function of copper-dependent protein binding depends on the specific protein and its role in the cell. For example, some copper-dependent proteins function as enzymes, while others act as structural components or signaling molecules. Understanding the molecular function of copper-dependent protein binding is crucial for understanding the role of copper in human health and disease. Copper deficiency or overload can lead to various pathological conditions, such as anemia, neurodegeneration, and cardiovascular disease. Studying the interaction of copper with proteins can provide insights into the mechanisms underlying these diseases and may facilitate the development of novel therapeutic strategies.'
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Proteins (1)

Compounds (7)