oxidized pyrimidine DNA binding

Definition

Target type: molecularfunction

Binding to a DNA region containing an oxidized pyrimidine residue. [GOC:vk]

Oxidized pyrimidine DNA binding is a molecular function associated with proteins that recognize and bind to oxidized pyrimidine bases in DNA. These bases, such as thymine glycol (Tg) and 5-hydroxycytosine (5-OHC), are generated by reactive oxygen species (ROS) and can cause DNA damage and mutations. Oxidized pyrimidine DNA binding proteins play a crucial role in DNA repair pathways, specifically in base excision repair (BER). They bind to the damaged bases, initiating the removal process by recruiting other BER enzymes. This binding is often highly specific to particular oxidized pyrimidine bases, ensuring efficient repair. For example, the protein thymine DNA glycosylase (TDG) specifically recognizes and removes Tg from DNA, while the enzyme endonuclease VIII (Nei) specifically removes 5-OHC. The binding of these proteins can also be influenced by the surrounding DNA sequence and structure, adding further specificity to their function. Overall, oxidized pyrimidine DNA binding is a vital process for maintaining genomic stability by recognizing and removing potentially mutagenic DNA lesions.'
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Proteins (1)

Compounds (2)