oxidized purine DNA binding
Definition
Target type: molecularfunction
Binding to a DNA region containing an oxidized purine residue. [GOC:vk]
Oxidized purine DNA binding refers to the interaction of proteins with DNA that contains oxidized purine bases. Purines, adenine (A) and guanine (G), are essential building blocks of DNA. Oxidative stress can damage DNA, leading to the formation of various oxidized purine lesions, such as 8-oxo-7,8-dihydroguanine (8-oxoG), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy-adenine), and others. These lesions can disrupt DNA replication and transcription, contributing to mutagenesis and genomic instability. Proteins that recognize and bind to oxidized purines play crucial roles in DNA repair pathways, preventing the accumulation of DNA damage and maintaining genomic integrity. Oxidized purine DNA binding proteins employ diverse mechanisms to recognize these damaged bases, often involving specific amino acid residues and structural features that interact with the modified purine and its surrounding DNA context. Examples of oxidized purine DNA binding proteins include:
- **Formamidopyrimidine DNA glycosylase (FPG)**: This protein removes Fapy-adenine and other oxidized purine lesions from DNA through its DNA glycosylase activity.
- **8-oxoguanine DNA glycosylase (OGG1)**: OGG1 specifically removes 8-oxoG from DNA, preventing its mispairing with adenine during replication.
- **MutY DNA glycosylase**: MutY is involved in removing adenine mispaired with 8-oxoG, preventing its incorporation into the genome during DNA replication. The binding of these proteins to oxidized purines initiates DNA repair pathways, such as base excision repair (BER), which removes the damaged base and restores the original DNA sequence. By recognizing and binding to oxidized purines, these proteins play a critical role in protecting the genome from oxidative damage and maintaining genomic stability.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| 40S ribosomal protein S3 | A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23396] | Homo sapiens (human) |
| N-glycosylase/DNA lyase | An N-glycosylase/DNA lyase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15527] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| hydralazine | hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent. Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent. | azaarene; hydrazines; ortho-fused heteroarene; phthalazines | antihypertensive agent; vasodilator agent |
| isocarboxazid | Isocarboxazid: An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311) | benzenes | |
| isoniazid | Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC). | carbohydrazide | antitubercular agent; drug allergen |
| nialamide | Nialamide: An MAO inhibitor that is used as an antidepressive agent. | organonitrogen compound; organooxygen compound | |
| hydralazine hydrochloride | hydralazine hydrochloride : The hydrochloride salt of hydralazine; a direct-acting vasodilator that is used as an antihypertensive agent. | hydrochloride | antihypertensive agent; vasodilator agent |
| gentamicin sulfate | |||
| PF-06446846 | PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. PF-06446846: inhibits translation of PCSK9 ;structure in first source | benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine | antilipemic drug; EC 3.4.21.61 (kexin) inhibitor |