SUMO binding

Definition

Target type: molecularfunction

Binding to the small ubiquitin-like protein SUMO. [GOC:mah]

SUMOylation is a post-translational modification in which a small ubiquitin-like modifier (SUMO) protein is covalently attached to a target protein. SUMO binding refers to the interaction between a SUMO protein and its target protein. This interaction is typically mediated by a SUMO-interacting motif (SIM), which is a short, conserved sequence of amino acids that binds to the SUMO protein. SUMO binding can have a variety of effects on target proteins, including:

* **Altering protein stability:** SUMOylation can either increase or decrease the stability of a target protein, depending on the specific protein and the context.
* **Modulating protein activity:** SUMOylation can regulate the activity of target proteins by influencing their interactions with other proteins or by affecting their localization within the cell.
* **Changing protein localization:** SUMOylation can direct target proteins to specific subcellular compartments, such as the nucleus or cytoplasm.

The specific function of SUMO binding depends on the target protein and the cellular context. In general, SUMOylation is involved in a wide range of cellular processes, including:

* **Transcriptional regulation:** SUMOylation plays a role in the regulation of gene expression by modifying the activity of transcription factors and other proteins involved in transcription.
* **DNA repair:** SUMOylation is involved in DNA repair pathways, including the repair of double-strand breaks.
* **Cell cycle control:** SUMOylation regulates the progression of the cell cycle by modifying the activity of cell cycle regulators.
* **Stress response:** SUMOylation is involved in the cellular response to stress, including heat shock and oxidative stress.

SUMO binding is a complex and dynamic process that is essential for the proper function of many cellular pathways. The precise mechanisms by which SUMO binding regulates target protein function are still being elucidated, but it is clear that this process plays a critical role in maintaining cellular homeostasis.'
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Proteins (1)

Compounds (1)