Target type: molecularfunction
Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. [GOC:mcc, PMID:16337230]
SAM domain binding is a protein-protein interaction that plays a crucial role in various cellular processes. SAM domains are protein modules consisting of approximately 50-70 amino acids, often found in proteins involved in signal transduction, chromatin remodeling, and cytoskeletal organization. These domains are characterized by a conserved tertiary structure consisting of five alpha helices that form a compact globular shape. This unique structure enables SAM domains to bind to other SAM domains, forming homotypic interactions. Additionally, SAM domains can interact with other protein domains, including SH3 domains, PSD-95/Dlg/ZO-1 (PDZ) domains, and WWE domains. These heterotypic interactions contribute to the diverse functions of SAM domain-containing proteins. SAM domain binding often mediates the assembly of protein complexes and scaffolds, which are critical for regulating cellular processes. For instance, in signal transduction pathways, SAM domain interactions can facilitate the recruitment and activation of downstream signaling molecules. Furthermore, SAM domains participate in the regulation of gene expression by modulating chromatin structure. By interacting with other proteins involved in chromatin remodeling, SAM domain-containing proteins can influence the accessibility of DNA to transcription factors. In the context of cytoskeletal organization, SAM domain binding contributes to the assembly and stability of cytoskeletal structures. These interactions can regulate cell morphology, migration, and adhesion. Overall, SAM domain binding serves as a versatile molecular mechanism that enables protein-protein interactions crucial for diverse cellular functions. It plays a significant role in signal transduction, gene expression, and cytoskeletal organization, highlighting its importance in maintaining cellular integrity and function.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Lethal(3)malignant brain tumor-like protein 1 | A lethal(3)malignant brain tumor-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y468] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| bifemelane | bifemelane: structure given in first source | diarylmethane | |
| chlorpheniramine | chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. | monochlorobenzenes; pyridines; tertiary amino compound | anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor |
| maprotiline | Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. | anthracenes | |
| oxybutynin | oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder. oxybutynin: RN given refers to parent cpd | acetylenic compound; carboxylic ester; racemate; tertiary alcohol; tertiary amino compound | antispasmodic drug; calcium channel blocker; local anaesthetic; muscarinic antagonist; muscle relaxant; parasympatholytic |
| cefsulodin | cefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic. Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients. | cephalosporin; organosulfonic acid; primary carboxamide | antibacterial drug |
| (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone | aromatic carboxylic acid; pyridinemonocarboxylic acid | ||
| entecavir | benzamides; N-acylpiperidine |