P2Y1 nucleotide receptor binding
Definition
Target type: molecularfunction
Binding to a P2Y1 nucleotide receptor. [GOC:mah, GOC:nln]
P2Y1 nucleotide receptor binding is a crucial cellular process involving the interaction of the P2Y1 receptor with its specific ligand, adenosine triphosphate (ATP). This binding event initiates a cascade of intracellular signaling events that ultimately lead to a variety of physiological responses.
The P2Y1 receptor, a G protein-coupled receptor (GPCR), is embedded in the cell membrane and possesses an extracellular domain that specifically recognizes and binds ATP. Upon ATP binding, the receptor undergoes a conformational change, activating its associated G protein, typically a Gq protein.
The activated Gq protein triggers the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the enzyme phospholipase C (PLC). This hydrolysis generates two important second messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG).
IP3 diffuses to the endoplasmic reticulum (ER) where it binds to IP3 receptors, causing the release of calcium ions (Ca2+) from intracellular stores. This increase in cytosolic Ca2+ concentration serves as a trigger for a wide range of downstream signaling events, including muscle contraction, neurotransmitter release, and enzyme activation.
DAG, on the other hand, remains in the plasma membrane and activates protein kinase C (PKC). PKC is a family of serine/threonine kinases that phosphorylate a variety of intracellular proteins, further amplifying the cellular response to ATP binding.
The P2Y1 receptor pathway is involved in numerous physiological processes, including vascular smooth muscle contraction, platelet aggregation, neuronal signaling, and inflammation. Dysregulation of P2Y1 receptor signaling has been implicated in various pathological conditions, such as cardiovascular disease, thrombosis, and cancer.
In summary, P2Y1 nucleotide receptor binding initiates a complex intracellular signaling cascade, involving the activation of G proteins, hydrolysis of PIP2, production of second messengers like IP3 and DAG, and subsequent activation of downstream signaling pathways, ultimately leading to a variety of physiological responses.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Disks large homolog 4 | A disks large homolog 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78352] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tat-nr2b9c | Tat-NR2B9c: a synthetic peptide consisting of the C-terminal 9 amino acids of the NR2B subunit of the NMDA receptor fused to the cell membrane protein transduction domain of the HIV-1-Tat protein |