Target type: molecularfunction
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]
Protein tag activity refers to the ability of a protein, often a short peptide sequence, to bind to a specific molecule or structure. These tags can be used for a variety of purposes in molecular biology and biotechnology, including protein purification, localization, and detection. The molecular function of a protein tag can be described by its interaction with other molecules and its ability to facilitate or alter their activity. For example, a protein tag might bind to an antibody, a specific enzyme, or a particular cellular compartment. The tag can then be used to purify the protein of interest, track its movement within a cell, or monitor its interaction with other molecules. The specific function of a protein tag is dependent on its sequence and structure, and can be tailored to a particular application.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| NEDD8 | A NEDD8 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15843] | Homo sapiens (human) |
| Ubiquitin-40S ribosomal protein S27a | A ubiquitin-ribosomal protein eS31 fusion protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62979] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gentamicin sulfate | |||
| pevonedistat | pevonedistat : A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. pevonedistat: a potent and selective inhibitor of NAE (NEDD8-activating enzyme) | cyclopentanols; indanes; pyrrolopyrimidine; secondary amino compound; sulfamidate | antineoplastic agent; apoptosis inducer |
| PF-06446846 | PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. PF-06446846: inhibits translation of PCSK9 ;structure in first source | benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine | antilipemic drug; EC 3.4.21.61 (kexin) inhibitor |