U2 snRNA binding

Definition

Target type: molecularfunction

Binding to a U2 small nuclear RNA (U2 snRNA). [GOC:jl]

U2 snRNA binding is a crucial molecular function in the process of pre-mRNA splicing, a vital step in gene expression. U2 snRNA is a component of the spliceosome, a large ribonucleoprotein complex that removes introns from precursor messenger RNA (pre-mRNA) molecules. During splicing, U2 snRNA recognizes and binds to the branch point sequence within the intron, a highly conserved adenine nucleotide. This binding event is essential for the proper formation of the spliceosome and the subsequent steps of intron removal. The interaction between U2 snRNA and the branch point sequence is mediated by base pairing, which involves the formation of hydrogen bonds between complementary nucleotides. The U2 snRNA molecule contains a specific sequence that is complementary to the branch point sequence, allowing for precise recognition and binding. This recognition is crucial for the accurate removal of introns and the production of mature messenger RNA (mRNA) molecules. Once U2 snRNA is bound to the branch point sequence, it facilitates the recruitment of other spliceosomal components, including the U1 snRNP, U4/U6 snRNP, and U5 snRNP. These components assemble into a functional spliceosome, which catalyzes the two-step transesterification reactions required for intron removal. The U2 snRNA binding step is therefore a critical regulatory point in pre-mRNA splicing, ensuring that introns are excised accurately and efficiently.'
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Proteins (1)

Compounds (4)