U2 snRNA binding
Definition
Target type: molecularfunction
Binding to a U2 small nuclear RNA (U2 snRNA). [GOC:jl]
U2 snRNA binding is a crucial molecular function in the process of pre-mRNA splicing, a vital step in gene expression. U2 snRNA is a component of the spliceosome, a large ribonucleoprotein complex that removes introns from precursor messenger RNA (pre-mRNA) molecules. During splicing, U2 snRNA recognizes and binds to the branch point sequence within the intron, a highly conserved adenine nucleotide. This binding event is essential for the proper formation of the spliceosome and the subsequent steps of intron removal. The interaction between U2 snRNA and the branch point sequence is mediated by base pairing, which involves the formation of hydrogen bonds between complementary nucleotides. The U2 snRNA molecule contains a specific sequence that is complementary to the branch point sequence, allowing for precise recognition and binding. This recognition is crucial for the accurate removal of introns and the production of mature messenger RNA (mRNA) molecules. Once U2 snRNA is bound to the branch point sequence, it facilitates the recruitment of other spliceosomal components, including the U1 snRNP, U4/U6 snRNP, and U5 snRNP. These components assemble into a functional spliceosome, which catalyzes the two-step transesterification reactions required for intron removal. The U2 snRNA binding step is therefore a critical regulatory point in pre-mRNA splicing, ensuring that introns are excised accurately and efficiently.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Splicing factor 3B subunit 3 | A splicing factor 3B subunit 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15393] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| trichostatin a | trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES | antibiotic antifungal agent; hydroxamic acid; trichostatin | bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector |
| tacrolimus | tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. | macrolide lactam | bacterial metabolite; immunosuppressive agent |
| lactacystin | lactam; S-substituted L-cysteine | ||
| e 7107 | E 7107: has antineoplastic activity |