Page last updated: 2024-10-24

kynureninase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. [EC:3.7.1.3]

Kynureninase activity is a crucial step in the kynurenine pathway, a major route for tryptophan catabolism. The enzyme catalyzes the hydrolytic cleavage of L-kynurenine to anthranilic acid and alanine. This reaction involves the removal of an amino group from L-kynurenine, which is then transferred to a water molecule to form alanine. The resulting anthranilic acid can then be further metabolized to various downstream products, including nicotinamide adenine dinucleotide (NAD+), a vital coenzyme in cellular metabolism. The molecular function of kynureninase activity is thus essential for the production of NAD+ and the detoxification of tryptophan metabolites. Furthermore, the kynurenine pathway plays a role in immune response, neurotransmission, and inflammation. Aberrant activity of kynureninase can contribute to various pathologies, including neurodegenerative disorders, autoimmune diseases, and cancer.'
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Proteins (1)

ProteinDefinitionTaxonomy
KynureninaseA kynureninase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16719]Homo sapiens (human)

Compounds (3)

CompoundDefinitionClassesRoles
3-hydroxykynurenine3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.

3-hydroxykynurenine: RN given refers to cpd without isomeric designation

hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
hydroxykynureninehuman metabolite
kynurenineL-kynurenine : A kynurenine that has L configuration.amino acid zwitterion;
kynurenine;
non-proteinogenic L-alpha-amino acid
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-hydroxyhippuric acid3-hydroxyhippuric acid: a kynureninase inhibitor; structure in first source

m-hydroxyhippuric acid : An N-acylglycine that is hippuric acid (N-benzoylglycine) substituted at position 3 on the phenyl ring by a hydroxy group.
N-acylglycine;
phenols
metabolite