Compounds > 3-hydroxyhippuric acid
Page last updated: 2024-11-08

3-hydroxyhippuric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-hydroxyhippuric acid: a kynureninase inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

m-hydroxyhippuric acid : An N-acylglycine that is hippuric acid (N-benzoylglycine) substituted at position 3 on the phenyl ring by a hydroxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID450268
CHEMBL ID447627
CHEBI ID70824
SCHEMBL ID600772
MeSH IDM0529684

Synonyms (42)

Synonym
unii-17hcx0hnrt
17hcx0hnrt ,
glycine, n-(3-hydroxybenzoyl)-
3xh ,
3-hydroxyhippuric acid
3-hydroxybenzoylglycine
[(3-hydroxybenzoyl)amino]acetic acid
n-(3-hydroxybenzoyl)glycine
m-hydroxyhippuric acid
2-[(3-hydroxybenzoyl)amino]acetic acid
2-[(3-hydroxyphenyl)formamido]acetic acid
DB07069
n-m-hydroxylbenzoylglycine
bdbm50265459
CHEMBL447627 ,
chebi:70824 ,
AKOS000128280
1637-75-8
EN300-54417
(3-hydroxybenzoylamino)acetic acid
hippuric acid, m-hydroxy-
hydroxyhippuric acid, m-
SCHEMBL600772
(3-hydroxy-benzoyl amino)-acetic acid
XDOFWFNMYJRHEW-UHFFFAOYSA-N
(3-hydroxy-benzoylamino)-acetic acid
mfcd09044170
HMS3604N06
DTXSID30167650
J-010089
BS-13947
(3-hydroxybenzoyl)glycine
HY-113085
CS-0059522
n-[(3-hydroxyphenyl)carbonyl]glycine
Q27095984
3-hydroxyhippuricacid
B2699-167342
m-hydroxyhippuricacid
n-(3-hydroxybenzoyl)-glycine
Z239129930
[(3-hydroxyphenyl)formamido]acetic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
N-acylglycineAn N-acyl-amino acid in which amino acid specified is glycine.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Flavan-3-ol metabolic pathway070

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
tryptophan catabolic processKynureninaseHomo sapiens (human)
NAD biosynthetic processKynureninaseHomo sapiens (human)
quinolinate biosynthetic processKynureninaseHomo sapiens (human)
response to type II interferonKynureninaseHomo sapiens (human)
'de novo' NAD biosynthetic process from tryptophanKynureninaseHomo sapiens (human)
response to vitamin B6KynureninaseHomo sapiens (human)
anthranilate metabolic processKynureninaseHomo sapiens (human)
L-kynurenine catabolic processKynureninaseHomo sapiens (human)
tryptophan catabolic process to kynurenineKynureninaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
pyridoxal phosphate bindingKynureninaseHomo sapiens (human)
kynureninase activityKynureninaseHomo sapiens (human)
protein homodimerization activityKynureninaseHomo sapiens (human)
3-hydroxykynureninase activityKynureninaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleoplasmKynureninaseHomo sapiens (human)
mitochondrionKynureninaseHomo sapiens (human)
cytosolKynureninaseHomo sapiens (human)
cytoplasmKynureninaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID412639Inhibition of human kynureninase2009Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.76 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-hydroxykynurenine
3-hydroxykynurenine: RN given refers to cpd without isomeric designation. 3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.. hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.		2.0510hydroxykynureninehuman metabolite
dihydro-3-coumaric acid
dihydro-3-coumaric acid: intermediate in biosynthesis of dihydrophenanthrenes from phenylalanine. 3-(3-hydroxyphenyl)propanoic acid : A monocarboxylic acid that is propionic acid carrying a 3-hydroxyphenyl substituent at C-3.		3.4611monocarboxylic acidEscherichia coli metabolite;
human xenobiotic metabolite
allantoin
[no description available]		2.0710imidazolidine-2,4-dione;
ureas		Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite;
vulnerary
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		3.4611trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
hippuric acid
hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591. N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.		7.0510N-acylglycinehuman blood serum metabolite;
uremic toxin
glycine
[no description available]		2.0710alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		3.4611benzenetriol;
phenolic donor		plant metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.2510pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
caffeine
[no description available]		2.2510purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
trigonelline
trigonelline: in hydra among other organisms; RN given refers to hydroxide inner salt; structure. N-methylnicotinic acid : A pyridinium ion consisting of nicotinic acid having a methyl substituent on the pyridine nitrogen.. N-methylnicotinate : An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.		2.2510alkaloid;
iminium betaine		food component;
human urinary metabolite;
plant metabolite
alloxan
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.. alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.		2.0710pyrimidonehyperglycemic agent;
metabolite
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		3.4611amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.0710mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
syringic acid
syringic acid: RN given refers to parent cpd; structure in third source. syringic acid : A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.		3.4611benzoic acids;
dimethoxybenzene;
phenols		plant metabolite
3-hydroxybenzeneacetic acid
3-hydroxybenzeneacetic acid: metabolite of L-dopa; structure. 3-hydroxyphenylacetic acid : A monocarboxylic acid that is phenylacetic acid in which the hydrogen at position 3 on the benzene ring is replaced by a hydroxy group.		3.8921monocarboxylic acid;
phenols		human xenobiotic metabolite
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid : A dihydroxy monocarboxylic acid that is 3-hydroxypropanoic acid substituted by a 3-hydroxyphenyl group at position 3.		2.1310dihydroxy monocarboxylic acid;
phenols		human urinary metabolite
5-acetylamino-6-formylamino-3-methyluracil
5-acetylamino-6-formylamino-3-methyluracil: metabolite of caffeine		2.2510formamidopyrimidinemouse metabolite
kynurenine
L-kynurenine : A kynurenine that has L configuration.		2.0510amino acid zwitterion;
kynurenine;
non-proteinogenic L-alpha-amino acid		human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Age-Related Osteoporosis
[description not available]		02.2510
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.2510
Autism Spectrum Disorder
Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)		07.1310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1310