inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. [GOC:ai]

Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity catalyzes the hydrolysis of the 3-phosphate group of inositol 1,3,4,5,6-pentakisphosphate (InsP5) to generate inositol 1,4,5,6-tetrakisphosphate (InsP4). This enzymatic activity plays a crucial role in regulating intracellular signaling pathways by modulating the levels of these inositol phosphate messengers. InsP5 is a potent second messenger involved in diverse cellular processes, including calcium signaling, membrane trafficking, and gene expression. The hydrolysis of InsP5 by 3-phosphatases reduces its cellular concentration, thereby fine-tuning the downstream signaling events. The specific molecular mechanism of this reaction involves the formation of a transient phosphoenzyme intermediate, followed by the release of inorganic phosphate and InsP4. The 3-phosphatase activity is often regulated by protein-protein interactions, post-translational modifications, and changes in cellular conditions, such as pH or calcium levels. This intricate regulation ensures the appropriate and timely response to various stimuli and the proper functioning of the signaling pathways that depend on inositol phosphates.'
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Proteins (1)

Compounds (1)