C-X-C chemokine binding

Definition

Target type: molecularfunction

Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]

C-X-C chemokine binding is a molecular function that involves the interaction of a protein with a specific class of chemokines known as C-X-C chemokines. These chemokines are characterized by the presence of two cysteine residues separated by a single amino acid residue. The binding of a C-X-C chemokine to its receptor initiates a signaling cascade that leads to a variety of cellular responses, including chemotaxis, cell activation, and inflammation. The interaction between a C-X-C chemokine and its receptor is highly specific, and different chemokines bind to distinct receptors. This specificity is crucial for directing the movement and activation of specific cell types in response to different stimuli. The binding of a C-X-C chemokine to its receptor is mediated by the chemokine's N-terminal domain, which interacts with the receptor's extracellular domain. The interaction is often stabilized by the formation of hydrogen bonds and hydrophobic interactions. Once the chemokine binds to its receptor, the receptor undergoes a conformational change that activates intracellular signaling pathways. These pathways can involve a variety of signaling molecules, including G proteins, tyrosine kinases, and phospholipases. The activation of these signaling pathways leads to a variety of cellular responses, including the activation of transcription factors, the production of cytokines, and the mobilization of intracellular calcium. Overall, C-X-C chemokine binding plays a critical role in a variety of physiological and pathological processes, including immune responses, inflammation, wound healing, and cancer metastasis. The specificity of this interaction ensures that different cell types are activated in response to specific chemokines, enabling a precise and coordinated response to various stimuli.'
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Proteins (2)

Compounds (6)