Target type: molecularfunction
Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]
C-X-C chemokine binding is a molecular function that involves the interaction of a protein with a specific class of chemokines known as C-X-C chemokines. These chemokines are characterized by the presence of two cysteine residues separated by a single amino acid residue. The binding of a C-X-C chemokine to its receptor initiates a signaling cascade that leads to a variety of cellular responses, including chemotaxis, cell activation, and inflammation. The interaction between a C-X-C chemokine and its receptor is highly specific, and different chemokines bind to distinct receptors. This specificity is crucial for directing the movement and activation of specific cell types in response to different stimuli. The binding of a C-X-C chemokine to its receptor is mediated by the chemokine's N-terminal domain, which interacts with the receptor's extracellular domain. The interaction is often stabilized by the formation of hydrogen bonds and hydrophobic interactions. Once the chemokine binds to its receptor, the receptor undergoes a conformational change that activates intracellular signaling pathways. These pathways can involve a variety of signaling molecules, including G proteins, tyrosine kinases, and phospholipases. The activation of these signaling pathways leads to a variety of cellular responses, including the activation of transcription factors, the production of cytokines, and the mobilization of intracellular calcium. Overall, C-X-C chemokine binding plays a critical role in a variety of physiological and pathological processes, including immune responses, inflammation, wound healing, and cancer metastasis. The specificity of this interaction ensures that different cell types are activated in response to specific chemokines, enabling a precise and coordinated response to various stimuli.'
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Protein | Definition | Taxonomy |
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Atypical chemokine receptor 3 | An atypical chemokine receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] | Homo sapiens (human) |
High mobility group protein B1 | A high mobility group protein B1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09429] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
salicylic acid | Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL). | monohydroxybenzoic acid | algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite |
diflunisal | diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position. Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN. | monohydroxybenzoic acid; organofluorine compound | non-narcotic analgesic; non-steroidal anti-inflammatory drug |
glycyrrhizic acid | glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. | enone; glucosiduronic acid; pentacyclic triterpenoid; tricarboxylic acid; triterpenoid saponin | EC 3.4.21.5 (thrombin) inhibitor; plant metabolite |
plerixafor | plerixafor : An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. plerixafor: a bicyclam derivate, highly potent & selective inhibitor of HIV-1 & HIV-2 | azacycloalkane; azamacrocycle; benzenes; crown amine; secondary amino compound; tertiary amino compound | anti-HIV agent; antineoplastic agent; C-X-C chemokine receptor type 4 antagonist; immunological adjuvant |
methotrexate | dicarboxylic acid; monocarboxylic acid amide; pteridines | abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent | |
cyclo(d-tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-glycyl) | oligopeptide |