mannokinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. [EC:2.7.1.7]

Mannokinase activity is a crucial step in the metabolism of mannose, a simple sugar that is an essential component of glycoproteins and other complex carbohydrates. This enzymatic activity catalyzes the phosphorylation of mannose, converting it to mannose 6-phosphate. This reaction is critical for several cellular processes, including:

1. **Glycoprotein biosynthesis:** Mannose 6-phosphate is a key intermediate in the synthesis of N-linked glycoproteins, complex sugars that play essential roles in protein folding, stability, and trafficking.

2. **Mannose salvage pathway:** The mannose salvage pathway allows cells to recycle mannose from degraded glycoproteins. Mannokinase activity is essential for this pathway, as it converts free mannose back into mannose 6-phosphate, which can then be incorporated into newly synthesized glycoproteins.

3. **Glycogen metabolism:** Mannose 6-phosphate can be further metabolized into fructose 6-phosphate, a key intermediate in glycolysis and glycogen biosynthesis.

4. **Regulation of intracellular signaling pathways:** Mannose 6-phosphate can also act as a signaling molecule, regulating the activity of various intracellular pathways.

In summary, mannokinase activity is a crucial enzyme that plays a central role in several cellular processes, including glycoprotein biosynthesis, mannose salvage, glycogen metabolism, and intracellular signaling. Its importance is underscored by its involvement in a variety of human diseases, including diabetes, cancer, and congenital disorders.
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Proteins (1)

Compounds (7)