Page last updated: 2024-10-24

deoxynucleoside kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145]

Deoxynucleoside kinase activity is a crucial molecular function involved in the metabolism of DNA precursors. It catalyzes the phosphorylation of deoxyribonucleosides (dNs), which are the building blocks of DNA. This phosphorylation process is essential for converting inactive dNs into their active forms, known as deoxyribonucleoside monophosphates (dNMPs). dNMPs serve as substrates for subsequent enzymatic reactions, including the synthesis of DNA.

Deoxynucleoside kinases exhibit substrate specificity, meaning that they preferentially phosphorylate specific dNs. For instance, some deoxynucleoside kinases specifically phosphorylate deoxyadenosine (dA), while others prefer deoxyguanosine (dG) or deoxycytidine (dC).

This enzymatic activity is crucial for maintaining a balanced pool of dNMPs, which is essential for proper DNA replication and repair. Dysregulation of deoxynucleoside kinase activity can lead to various diseases, including cancer and immune deficiencies.'
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Proteins (1)

ProteinDefinitionTaxonomy
Thymidine kinase 2, mitochondrialA thymidine kinase 2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00142]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
cytarabinebeta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside
antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
thymine arabinosidethymine arabinoside: selectively inhibits replication of herpes simplex virusN-glycosyl compound
5-propyl-2'-deoxyuridine5-propyl-2'-deoxyuridine: RN given refers to parent cpd
sorivudineorganic molecular entity
9-arabinofuranosylguanine9-arabinofuranosylguanine: RN given refers to (beta)-isomer

9-beta-D-arabinofuranosylguanine : A purine nucleoside in which guanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. It inhibits DNA synthesis and causes cell death.
beta-D-arabinoside;
purine nucleoside
antineoplastic agent;
DNA synthesis inhibitor