deoxyhypusine monooxygenase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. [EC:1.14.99.29]
Deoxyhypusine monooxygenase (DHPS) catalyzes the conversion of deoxyhypusine to hypusine, a unique amino acid found in eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for the function of eIF5A, which is involved in a variety of cellular processes, including translation elongation, cell proliferation, and stress response. The mechanism of the reaction catalyzed by DHPS involves the oxidation of the deoxyhypusine residue by molecular oxygen to form hypusine. This oxidation is a two-step process that involves the formation of a reactive intermediate, which is then reduced by NADPH. The overall reaction catalyzed by DHPS is: Deoxyhypusine + O2 + NADPH + H+ → Hypusine + H2O + NADP+.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Deoxyhypusine hydroxylase | A deoxyhypusine hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BU89] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2,2'-dipyridyl | 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. 2,2'-Dipyridyl: A reagent used for the determination of iron. | bipyridine | chelator; ferroptosis inhibitor |
| ciclopirox | cyclic hydroxamic acid; hydroxypyridone antifungal drug; pyridone | antibacterial agent; antiseborrheic | |
| deferiprone | deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA. | 4-pyridones | iron chelator; protective agent |
| deferoxamine | Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. | acyclic desferrioxamine | bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore |
| mimosine | L-mimosine : An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica. | 4-pyridones; amino acid zwitterion; non-proteinogenic L-alpha-amino acid | EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite |