phosphotransferase activity, for other substituted phosphate groups

Definition

Target type: molecularfunction

Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). [GOC:jl]

Phosphotransferase activity, for other substituted phosphate groups, refers to the enzymatic ability to transfer a phosphate group from a donor molecule to an acceptor molecule. This transfer is not limited to simple phosphate groups, but includes those with modifications or substitutions. The donor molecule can be a variety of compounds, including ATP, GTP, or other phosphorylated molecules. The acceptor molecule can be a wide range of substrates, including proteins, carbohydrates, lipids, and nucleic acids.

This type of enzymatic activity plays a crucial role in various cellular processes, including:

* **Signal transduction:** Phosphotransferases can modify proteins by adding phosphate groups, altering their activity and initiating signaling cascades.
* **Metabolism:** Phosphotransferases are involved in many metabolic pathways, such as glycolysis, gluconeogenesis, and the citric acid cycle, where they transfer phosphate groups to intermediates.
* **DNA replication and repair:** Phosphotransferases are involved in the process of DNA replication and repair, ensuring the accurate copying and maintenance of genetic information.

The specificity of the enzyme is determined by the structure of the active site, which recognizes and binds to both the donor and acceptor molecules. The transfer of the phosphate group is often coupled to a conformational change in the enzyme, which promotes the reaction and releases the products.

The study of phosphotransferases is vital for understanding cellular processes and developing therapeutic strategies for various diseases. By understanding their mechanisms and specificity, researchers can design inhibitors to target specific phosphotransferases involved in disease pathogenesis.'
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Proteins (1)

Compounds (2)