acylglycerol O-acyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. [GOC:ai]

Acylglycerol O-acyltransferase activity refers to the enzymatic process of transferring an acyl group from an acyl donor, such as fatty acyl-CoA, to an acylglycerol molecule. This reaction is a key step in the synthesis of triglycerides, the primary form of energy storage in many organisms. Acyltransferases involved in this process typically exhibit specificity towards the position of glycerol that is acylated. For example, some enzymes may prefer to add fatty acids to the sn-1 or sn-3 position of glycerol, while others may exhibit broader substrate specificity. The reaction typically occurs in the endoplasmic reticulum (ER) of cells, where the enzymes are localized and interact with the necessary substrates. The activity of acylglycerol O-acyltransferases is crucial for maintaining lipid homeostasis and regulating energy storage. It also plays a role in various biological processes, including membrane biogenesis, cell signaling, and the production of bioactive lipids. Dysregulation of acylglycerol O-acyltransferase activity can contribute to the development of metabolic disorders such as obesity and diabetes.'
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Proteins (2)

Compounds (1)