phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity refers to the enzymatic activity that specifically removes the phosphate group from the 3-position of phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 is a crucial signaling molecule involved in various cellular processes, including cell growth, proliferation, survival, and migration. The dephosphorylation of PIP3 by these phosphatases, often called PTEN (phosphatase and tensin homolog deleted on chromosome ten), results in the generation of phosphatidylinositol-4,5-bisphosphate (PIP2). This conversion effectively downregulates the PIP3 signaling pathway, acting as a critical regulatory mechanism. This dephosphorylation plays a vital role in modulating downstream signaling cascades initiated by PIP3, ultimately influencing cell fate and behavior. The molecular function of these phosphatases is thus to act as negative regulators of the PIP3 signaling pathway, ensuring proper control over cellular processes that are dependent on PIP3 signaling.'
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Proteins (2)

Compounds (1)