chloride:monoatomic cation symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). [PMID:31747317]

Chloride:monoatomic cation symporters are transmembrane proteins that facilitate the simultaneous transport of chloride ions (Cl-) and monoatomic cations, such as sodium (Na+) or potassium (K+), across cell membranes. This transport is coupled, meaning that the movement of one ion is dependent on the movement of the other. The symporter protein binds to both Cl- and the cation on one side of the membrane. The binding event induces a conformational change in the protein, allowing the ions to move across the membrane together. This movement is typically driven by the electrochemical gradient of one or both of the ions. Chloride:monoatomic cation symporters play critical roles in various physiological processes, including:

- **Fluid and electrolyte balance:** Symporters contribute to the regulation of fluid volume and electrolyte concentrations in cells and tissues.
- **Cell volume regulation:** The transport of Cl- and cations can influence the osmotic pressure across the cell membrane, impacting cell volume.
- **Neurotransmission:** Symporters play a role in the reuptake of neurotransmitters, such as GABA, which are involved in neuronal signaling.
- **Kidney function:** Chloride:monoatomic cation symporters in the kidney contribute to the reabsorption of electrolytes and water, maintaining proper kidney function.

These symporters are vital for maintaining cellular homeostasis and proper physiological function in various tissues and organs.'
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Proteins (1)

Compounds (2)