calcium:monoatomic cation antiporter activity
Definition
Target type: molecularfunction
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]
Calcium:monoatomic cation antiporter activity is a molecular function that describes the movement of calcium ions (Ca2+) across a membrane against their concentration gradient. This process is essential for a wide range of cellular processes, including signal transduction, muscle contraction, and neurotransmission. Calcium:monoatomic cation antiporters are integral membrane proteins that use energy from another source, such as ATP hydrolysis, to drive the transport of calcium ions. The direction of transport can vary depending on the specific antiporter and the electrochemical gradient of calcium. For example, some antiporters transport calcium ions out of the cell, while others transport them into the cell. The activity of these antiporters is tightly regulated and plays a crucial role in maintaining calcium homeostasis within the cell. Disruptions in calcium:monoatomic cation antiporter activity can lead to a variety of diseases, including muscle disorders, neurological disorders, and heart disease.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Mitochondrial sodium/calcium exchanger protein | A mitochondrial sodium/calcium exchanger protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J4K2] | Homo sapiens (human) |
| Mitochondrial sodium/calcium exchanger protein | A mitochondrial sodium/calcium exchanger protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J4K2] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cgp 37157 | CGP 37157: benzothiazepine derivative of clonazepam; inhibits the in vitro activity of mitochondrial sodium-calcium exchange | benzothiazepine |