succinate transmembrane transporter activity
Definition
Target type: molecularfunction
Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. [ISBN:0198506732]
Succinate transmembrane transporter activity refers to the process by which succinate, a four-carbon dicarboxylic acid, is transported across cellular membranes. This transport is mediated by specific proteins known as succinate transporters, which facilitate the movement of succinate against its concentration gradient. Succinate transporters are essential for various cellular processes, including energy metabolism, redox balance, and the regulation of intracellular signaling pathways. The transport mechanism can be active or passive, depending on the transporter and the cellular context. Active transport requires energy input, usually derived from ATP hydrolysis, to move succinate against its electrochemical gradient. Passive transport relies on the concentration gradient or electrochemical potential across the membrane to drive succinate movement. The specific mechanism of transport can vary depending on the transporter, but generally involves the binding of succinate to a specific site on the transporter protein, followed by conformational changes that allow succinate to move across the membrane. Succinate transporters play critical roles in various physiological processes, including the citric acid cycle, oxidative phosphorylation, and the regulation of cellular redox state. Dysregulation of succinate transport can contribute to various pathological conditions, including cancer, metabolic disorders, and neurodegenerative diseases. '
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Solute carrier family 13 member 3 | A Na(+)/dicarboxylate cotransporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WWT9] | Homo sapiens (human) |
| Monocarboxylate transporter 1 | A monocarboxylate transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53985] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| succinic acid | succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) | alpha,omega-dicarboxylic acid; C4-dicarboxylic acid | anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent |
| ar c155858 | AR C155858: an MCT1 inhibitor; structure in first source | ||
| azd3965 | AZD3965: a monocarboxylate transporter-1 inhibitor with antineoplastic activity; structure in first source |