Target type: molecularfunction
Enables the transfer of iodide ions from one side of a membrane to the other. [GOC:ai]
Iodide transmembrane transporter activity involves the movement of iodide ions (I-) across cell membranes. This transport is essential for various physiological processes, particularly thyroid hormone synthesis. Iodide transmembrane transporters are membrane proteins that facilitate the passive or active movement of iodide ions against their concentration gradient. The precise mechanism of transport can vary depending on the specific transporter, but it often involves the binding of iodide ions to the transporter protein and their subsequent translocation across the membrane. Iodide transporters are found in various tissues, including the thyroid gland, salivary glands, mammary glands, and the gastrointestinal tract. In the thyroid gland, iodide transporters play a crucial role in the uptake of iodide from the bloodstream into thyroid follicular cells, where it is used for thyroid hormone synthesis. Iodide transport is a tightly regulated process that is influenced by various factors, including hormones, dietary intake, and the presence of other ions. Dysregulation of iodide transmembrane transporter activity can lead to various disorders, including hypothyroidism and hyperthyroidism.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Anoctamin-1 | An anoctamin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5XXA6] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| niclosamide | niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48) | benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide | anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor |
| nitazoxanide | nitazoxanide: a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug | benzamides; carboxylic ester | |
| n-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid | N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid: inhibits anoctamin-1; structure in first source | ||
| t16ainh-a01 | T16AInh-A01: a TMEM16A inhibitor |