phospholipase A1 activity

Definition

Target type: molecularfunction

Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. [EC:3.1.1.32]

Phospholipase A1 (PLA1) activity involves the hydrolysis of the ester bond at the sn-1 position of a phospholipid molecule, specifically targeting the fatty acid attached to the first carbon of the glycerol backbone. This enzymatic reaction liberates a free fatty acid, typically a saturated fatty acid, and generates a lysophospholipid.

PLA1 enzymes play crucial roles in various cellular processes, including:

* **Lipid signaling:** PLA1-derived lysophospholipids act as signaling molecules, modulating cellular responses, such as inflammation, cell growth, and apoptosis.
* **Membrane remodeling:** PLA1 activity can modify membrane composition, influencing membrane fluidity and permeability.
* **Digestion:** In the digestive system, PLA1 enzymes contribute to the breakdown of dietary phospholipids, facilitating the absorption of fatty acids.

The specific substrate specificity and regulation of PLA1 enzymes vary depending on the enzyme type and cellular context. These enzymes are often involved in complex signaling pathways, and their dysregulation can contribute to various pathological conditions.'
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Proteins (7)

Compounds (6)