Target type: molecularfunction
Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. [GOC:ai]
Protein kinase C (PKC) inhibitors are a class of molecules that block the activity of PKC, a family of serine/threonine-specific protein kinases that play crucial roles in cellular signaling pathways involved in a wide range of biological processes. PKC isoforms are activated by various stimuli, including calcium ions, diacylglycerol, and phosphatidylserine, and they regulate a diverse array of cellular events, such as cell growth, differentiation, apoptosis, and inflammation. PKC inhibitors exert their effects by interacting with the active site of PKC enzymes, preventing the phosphorylation of target proteins. This inhibition disrupts the downstream signaling cascades triggered by PKC activation, thereby interfering with the physiological responses mediated by these pathways. PKC inhibitors have shown promise in treating a variety of diseases, including cancer, cardiovascular disease, and inflammatory disorders. However, further research is needed to optimize their therapeutic potential and address potential side effects.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| 14-3-3 protein gamma | A 14-3-3 protein gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61981] | Homo sapiens (human) |
| Heat shock protein beta-1 | A heat shock protein beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04792] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| birb 796 | aromatic ether; morpholines; naphthalenes; pyrazoles; ureas | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; immunomodulator | |
| mrs2159 | MRS2159: an antagonist of both P2X1 and P2X7 receptors | ||
| sb 242235 | SB 242235: p38 MAP kinase antagonist | ||
| N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide | N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide : A dicarboxylic acid diamide obtained by condensation of the 3- and 4'-carboxy groups of 6-methyl[1,1'-biphenyl]-3,4'-dicarboxylic acid with cyclpropylamine and cyclpropylmethylamine respectively. | benzamides; biphenyls; cyclopropanes; dicarboxylic acid diamide | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| skepinone-l | skepinone-L: a dibenzosuberone-type p38 MAPK inhibitor; structure in first source | ||
| nsc751382 |