Page last updated: 2024-10-24

quercetin 2,3-dioxygenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. [EC:1.13.11.24, RHEA:15381]

Quercetin 2,3-dioxygenase activity refers to the enzymatic catalysis of the oxidative cleavage of the C-ring of quercetin, a flavonoid compound. This reaction involves the insertion of molecular oxygen into the 2,3-bond of quercetin, leading to the formation of 2-hydroxy-4,6-dihydroxybenzoic acid and protocatechuic acid. This activity is crucial in the catabolism of flavonoids, a major class of plant secondary metabolites. It plays a role in the detoxification and breakdown of quercetin, as well as in the production of various metabolites with potential biological activities.'
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Proteins (2)

ProteinDefinitionTaxonomy
PirinA pirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00625]Homo sapiens (human)
PirinA pirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00625]Homo sapiens (human)

Compounds (7)

CompoundDefinitionClassesRoles
chir-265aromatic ether
az-628AZ-628: a multikinase inhibitor; structure in first sourcebenzamides
GDC-0879indanes;
ketoxime;
primary alcohol;
pyrazoles;
pyridines
antineoplastic agent;
B-Raf inhibitor
plx 4720PLX 4720: a B-Raf(V600E) kinase inhibitor; structure in first sourcearomatic ketone;
difluorobenzene;
organochlorine compound;
pyrrolopyridine;
sulfonamide
antineoplastic agent;
B-Raf inhibitor
plx4032aromatic ketone;
difluorobenzene;
monochlorobenzenes;
pyrrolopyridine;
sulfonamide
antineoplastic agent;
B-Raf inhibitor
dabrafenib1,3-thiazoles;
aminopyrimidine;
organofluorine compound;
sulfonamide
anticoronaviral agent;
antineoplastic agent;
B-Raf inhibitor
tak-632TAK-632 : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.(trifluoromethyl)benzenes;
aromatic ether;
benzothiazoles;
cyclopropylcarboxamide;
monofluorobenzenes;
nitrile;
secondary carboxamide
antineoplastic agent;
apoptosis inducer;
B-Raf inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
necroptosis inhibitor