Page last updated: 2024-10-24
quercetin 2,3-dioxygenase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. [EC:1.13.11.24, RHEA:15381]
Quercetin 2,3-dioxygenase activity refers to the enzymatic catalysis of the oxidative cleavage of the C-ring of quercetin, a flavonoid compound. This reaction involves the insertion of molecular oxygen into the 2,3-bond of quercetin, leading to the formation of 2-hydroxy-4,6-dihydroxybenzoic acid and protocatechuic acid. This activity is crucial in the catabolism of flavonoids, a major class of plant secondary metabolites. It plays a role in the detoxification and breakdown of quercetin, as well as in the production of various metabolites with potential biological activities.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Pirin | A pirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00625] | Homo sapiens (human) |
| Pirin | A pirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00625] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| chir-265 | aromatic ether | ||
| az-628 | AZ-628: a multikinase inhibitor; structure in first source | benzamides | |
| GDC-0879 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor | |
| plx 4720 | PLX 4720: a B-Raf(V600E) kinase inhibitor; structure in first source | aromatic ketone; difluorobenzene; organochlorine compound; pyrrolopyridine; sulfonamide | antineoplastic agent; B-Raf inhibitor |
| plx4032 | aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide | antineoplastic agent; B-Raf inhibitor | |
| dabrafenib | 1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide | anticoronaviral agent; antineoplastic agent; B-Raf inhibitor | |
| tak-632 | TAK-632 : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively. | (trifluoromethyl)benzenes; aromatic ether; benzothiazoles; cyclopropylcarboxamide; monofluorobenzenes; nitrile; secondary carboxamide | antineoplastic agent; apoptosis inducer; B-Raf inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; necroptosis inhibitor |