Target type: molecularfunction
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. [EC:2.1.1.1, RHEA:23884]
Nicotinamide N-methyltransferase (NNMT) activity catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, a reaction that produces S-adenosyl-L-homocysteine (SAH) and N-methylnicotinamide (MNA). This enzymatic reaction is crucial in the metabolism of nicotinamide, a key component of NAD+, a coenzyme involved in numerous metabolic pathways. NNMT plays a role in regulating NAD+ levels and influencing various cellular processes, including:
- **NAD+ homeostasis:** NNMT consumes NAD+ to produce MNA, contributing to NAD+ depletion.
- **Redox balance:** NNMT activity affects the ratio of NAD+/NADH, which is essential for maintaining redox balance in cells.
- **Cellular signaling:** MNA, the product of NNMT activity, can act as a signaling molecule, influencing various cellular processes.
- **Metabolic regulation:** NNMT has been implicated in the regulation of lipid metabolism and glucose homeostasis.
- **Inflammation and immune response:** NNMT activity has been linked to inflammatory responses and immune cell function.
- **Cancer development:** NNMT expression and activity are often altered in cancer, suggesting a potential role in tumorigenesis.
Overall, NNMT activity is a critical enzyme in nicotinamide metabolism, influencing diverse cellular processes and playing a role in various physiological and pathological conditions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Nicotinamide N-methyltransferase | A nicotinamide N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40261] | Homo sapiens (human) |
| Nicotinamide N-methyltransferase | A nicotinamide N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40261] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| benzamide | benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides. | benzamides | |
| 1,2,3,4-tetrahydroisoquinoline | 1,2,3,4-tetrahydroisoquinoline: RN given refers to cpd with locants as specified | isoquinolines | |
| quinoline | azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines | ||
| isoquinoline | azaarene; isoquinolines; mancude organic heterobicyclic parent; ortho-fused heteroarene | ||
| 6-aminonicotinamide | 6-aminonicotinamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. 6-Aminonicotinamide: A vitamin antagonist which has teratogenic effects. | aminopyridine; monocarboxylic acid amide; primary amino compound | antimetabolite; EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor; teratogenic agent |
| sinefungin | adenosines; non-proteinogenic alpha-amino acid | antifungal agent; antimicrobial agent | |
| n'-methyl-2-pyridone-5-carboxamide | N-methyl-6-pyridone-3-carboxamide : A pyridone that is 2-pyridone substituted with a carboxamide group at C-5 and a methyl group at N-1. N'-methyl-2-pyridone-5-carboxamide: structure | methylpyridines; pyridinecarboxamide; pyridone | metabolite; mouse metabolite |
| 4-Methoxybenzamide | benzamides | ||
| n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid | |||
| s-adenosylhomocysteine | S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine. S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. | adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide | cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite |
| thionicotinamide | |||
| quinoline-3-carboxamide | quinoline-3-carboxamide: structure in first source |