choline:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). [TC:2.A.22.3.5]

Choline:sodium symporter activity is a membrane transport process that facilitates the simultaneous movement of choline and sodium ions across a cell membrane. This process is driven by the electrochemical gradient of sodium ions, which are typically at a higher concentration outside the cell than inside. The symporter protein binds both choline and sodium ions, and this binding event triggers a conformational change in the protein that allows the transport of both molecules into the cell. Choline:sodium symporters play a critical role in the uptake of choline into cells, which is essential for the synthesis of acetylcholine, a neurotransmitter that plays a crucial role in muscle contraction, memory, and learning. The activity of choline:sodium symporters can be regulated by various factors, including the concentration of choline and sodium ions, as well as by the presence of specific inhibitors or activators. Disruptions in choline:sodium symporter activity can lead to various neurological disorders, including Alzheimer's disease and Huntington's disease.'
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Proteins (1)

Compounds (3)