Target type: molecularfunction
Binding to a Type II interleukin-1 receptor. [GOC:ai]
Interleukin-1 receptor type II (IL-1RII) binding is a crucial step in the regulation of the immune response. IL-1RII acts as a decoy receptor for IL-1α and IL-1β, competing with the signaling receptor IL-1RI for ligand binding. This competition plays a critical role in modulating the pro-inflammatory effects of IL-1.
Upon binding to IL-1RII, the cytokine is unable to trigger downstream signaling pathways, effectively dampening the inflammatory cascade. This is due to the absence of a cytoplasmic Toll/IL-1 receptor (TIR) domain in IL-1RII, which is essential for the recruitment of adaptor proteins and activation of signaling cascades.
The binding of IL-1 to IL-1RII serves as a negative feedback mechanism, preventing excessive inflammation and maintaining immune homeostasis. This decoy receptor function of IL-1RII is particularly important in chronic inflammatory conditions, where it contributes to the resolution of inflammation and tissue repair.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Endoplasmic reticulum aminopeptidase 1 | An endoplasmic reticulum aminopeptidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NZ08] | Homo sapiens (human) |
| Interleukin-1 receptor antagonist protein | An interleukin-1 receptor antagonist protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P18510] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ubenimex | ubenimex: growth inhibitor | ||
| angiotensin ii, des-asp(1)-des-arg(2)-ile(5)- | angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-: 3-8 hexapeptide fragment of angiotensin II; smallest potent angiotensin II antagonist | organic molecular entity | |
| leucine phosphonic acid | leucine phosphonic acid: a leucine aminopeptidase antagonist; structure given in first source | ||
| 1-amino-3-phenylpropylphosphonic acid | 1-amino-3-phenylpropylphosphonic acid: inhibits L-phenylalanine ammonia-lyase activity of higher plants |