parathyroid hormone receptor activity

Definition

Target type: molecularfunction

Combining with parathyroid hormone to initiate a change in cell activity. [GOC:mah]

Parathyroid hormone receptor (PTHR) activity is a critical process in calcium homeostasis and bone metabolism. PTHR, a G protein-coupled receptor, is activated by parathyroid hormone (PTH) and its related peptide, parathyroid hormone-related protein (PTHrP). Upon binding of PTH or PTHrP to the extracellular domain of PTHR, a conformational change occurs in the receptor, leading to the activation of intracellular signaling pathways. This activation involves the coupling of PTHR to G proteins, particularly Gs, which stimulates the production of cyclic adenosine monophosphate (cAMP). cAMP then activates protein kinase A (PKA), initiating a cascade of downstream signaling events. These events include the phosphorylation of various proteins involved in calcium regulation and bone metabolism. PTHR activation leads to increased bone resorption, promoting the release of calcium from bone into the bloodstream. Simultaneously, it inhibits renal phosphate reabsorption, leading to increased phosphate excretion in urine. These actions contribute to the overall elevation of serum calcium levels. Moreover, PTHR signaling affects other cellular processes, such as cell proliferation and differentiation, contributing to the regulation of bone remodeling. Overall, PTHR activity plays a crucial role in maintaining calcium homeostasis, bone health, and overall organismal health.'
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Proteins (1)

Compounds (1)