Target type: molecularfunction
Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. [RHEA:15901]
Phosphoglycerate mutase (PGM) activity catalyzes the reversible isomerization of 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG). This reaction is a crucial step in glycolysis, the central metabolic pathway for energy production in most organisms. The enzyme utilizes a unique mechanism involving a histidine residue within its active site. This histidine residue is initially phosphorylated by 2PG, forming a phosphohistidine intermediate. This intermediate then transfers the phosphate group to 3PG, generating 2PG and regenerating the active enzyme. PGM activity is essential for glycolysis, as it allows for the conversion of 3PG, a substrate that is not readily utilized by subsequent enzymes, to 2PG, which can be further metabolized in the glycolytic pathway. The precise mechanism and regulation of PGM activity can vary depending on the specific enzyme and its cellular context. However, the overall function of PGM is to facilitate the efficient and reversible interconversion of 3PG and 2PG, ensuring the smooth operation of glycolysis and energy production.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Phosphoglycerate mutase 1 | A phosphoglycerate mutase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18669] | Homo sapiens (human) |
| Phosphoglycerate mutase 1 | A phosphoglycerate mutase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18669] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| xanthone | xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9. | xanthones | insecticide |
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| alizarin red s | alizarin red S : An organic sodium salt having 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate as the counterion. It is commonly used to stain embryo skeletons in cleared whole mounts, usually of small mammals. Alizarin Red S: RN given refers to parent cpd; structure | organic sodium salt; organosulfonate salt | histological dye |
| mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |
| gamma-mangostin | gamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. | phenols; xanthones | antineoplastic agent; plant metabolite; protein kinase inhibitor |