mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]

Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity is an enzymatic function that specifically removes terminal alpha-1,2-linked mannose residues from mannosyl-oligosaccharides. This activity is crucial for the processing and maturation of N-linked glycans, complex sugar structures that are attached to proteins. The enzyme cleaves the glycosidic bond between the alpha-1,2-linked mannose residue and the adjacent sugar residue in the oligosaccharide chain. This activity is essential for the proper folding, stability, and function of many glycoproteins. It is also involved in the degradation of glycoproteins and the regulation of glycoprotein trafficking. The removal of alpha-1,2-linked mannose residues by this enzyme is a critical step in the pathway that converts high-mannose oligosaccharides into complex N-glycans. This process is essential for the proper folding and function of many glycoproteins.'
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Proteins (2)

Compounds (1)