Target type: molecularfunction
Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46]
Fructose-2,6-bisphosphate 2-phosphatase (FBPase2) is an enzyme involved in the regulation of carbohydrate metabolism. It catalyzes the dephosphorylation of fructose-2,6-bisphosphate (F2,6BP) to fructose-6-phosphate (F6P) and inorganic phosphate (Pi). F2,6BP is a potent activator of phosphofructokinase 1 (PFK1), the key regulatory enzyme of glycolysis. By removing F2,6BP, FBPase2 inhibits glycolysis and promotes gluconeogenesis. FBPase2 plays a crucial role in maintaining glucose homeostasis. It is activated by glucagon and inhibited by insulin, reflecting its role in regulating glucose production and utilization. The enzyme is also involved in other metabolic pathways, including glycogen metabolism and lipid synthesis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16875] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one | 2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 6, 7, 8, and 4' respectively. | pentahydroxyflavone | |
| 4',7,8-trihydroxyisoflavone | 4',7,8-trihydroxyisoflavone: from Streptomyces sp OH-1049; structure given in first source | isoflavones | |
| 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase isozymes inhibitor; structure in first source | enone; pyridines | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor |