A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16875]
6PF-2-K/Fru-2,6-P2ase 3;
PFK/FBPase 3;
6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme;
Renal carcinoma antigen NY-REN-56;
iPFK-2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one | Homo sapiens (human) | IC50 | 2.9700 | 1 | 1 |
| 2-(4-hydroxyphenyl)-5,6,7,8-tetrahydroxy-4H-1-benzopyran-4-one | Homo sapiens (human) | Ki | 1.2900 | 1 | 1 |
| 4',7,8-trihydroxyisoflavone | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | Homo sapiens (human) | IC50 | 49.3000 | 3 | 3 |
| 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | Homo sapiens (human) | Ki | 25.1000 | 1 | 0 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| 6-phosphofructo-2-kinase activity | molecular function | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+. [EC:2.7.1.105, RHEA:15653] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| fructose-2,6-bisphosphate 2-phosphatase activity | molecular function | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| fructose metabolic process | biological process | The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [ISBN:0198506732] |
| carbohydrate phosphorylation | biological process | The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. [ISBN:0198506732] |
| fructose 2,6-bisphosphate metabolic process | biological process | The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. [ISBN:0198506732] |