Target type: molecularfunction
Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine. [EC:2.7.1.82, RHEA:13069]
Ethanolamine kinase activity catalyzes the phosphorylation of ethanolamine to form phosphoethanolamine. This reaction is the first committed step in the biosynthesis of phosphatidylethanolamine, a major phospholipid component of cell membranes. Ethanolamine kinase is a key enzyme in the metabolism of phospholipids, playing a crucial role in membrane biogenesis, signal transduction, and cell growth and development. The enzyme utilizes ATP as the phosphate donor and requires magnesium ions for optimal activity. Ethanolamine kinase activity is typically regulated by a variety of factors, including substrate availability, product inhibition, and phosphorylation. Variations in ethanolamine kinase activity have been implicated in a number of diseases, including cancer and neurodegenerative disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Choline kinase alpha | A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 4-dimethylaminopyridine | 4-dimethylaminopyridine: catalyst for acetylation of hydroxy cpds; structure | dialkylarylamine; tertiary amino compound | |
| 4-pyrrolidinopyridine | |||
| rsm-932a | RSM-932A: a choline kinase inhibitor with antimalarial activity; structure in first source |